Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract
dc.contributor.author | Lu, Yuan | |
dc.contributor.author | Starkey, Nicholas | |
dc.contributor.author | Lei, Wei | |
dc.contributor.author | Li, Jilong | |
dc.contributor.author | Cheng, Jianlin | |
dc.contributor.author | Folk, William R. | |
dc.contributor.author | Lubahn, Dennis | |
dc.date.accessioned | 2021-08-09T21:29:20Z | |
dc.date.available | 2021-08-09T21:29:20Z | |
dc.date.issued | 2015-12 | |
dc.description.abstract | Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cells with or without Sutherlandia extracts. We found 50% of Hh-responsive genes can be repressed by Sutherlandia ethanol extract, including the canonical Hh-responsive genes Gli1 and Ptch1 as well as newly distinguished Hh-responsive genes Hsd11b1 and Penk. | |
dc.description.department | Chemistry and Biochemistry | |
dc.format | Text | |
dc.format.extent | 9 pages | |
dc.format.medium | 1 file (.pdf) | |
dc.identifier.citation | Lu, Y., Starkey, N., Lei, W., Li, J., Cheng, J., Folk, W. R., & Lubahn, D. B. (2015). Inhibition of hedgehog-signaling driven genes in prostate cancer cells by Sutherlandia frutescens extract. PLoS One, 10(12), e0145507. | |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0145507 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/10877/14260 | |
dc.language.iso | en | |
dc.publisher | Public Library of Science | |
dc.rights.holder | © 2015 Lu et al. | |
dc.rights.license | This work is licensed under a Creative Commons Attribution 4.0 International License. | |
dc.source | PLoS One, 2015, Vol. 10, No. 12, Article e0145507. | |
dc.subject | prostate cancer | |
dc.subject | gene expression | |
dc.subject | cancer treatment | |
dc.subject | colorectal cancer | |
dc.subject | small cell lung cancer | |
dc.subject | gene ontologies | |
dc.subject | ethanol | |
dc.subject | prostate gland | |
dc.subject | Chemistry and Biochemistry | |
dc.title | Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract | |
dc.type | Article |