Intermolecular Interactions of G-Triplex DNA Assessed by Multi-Channel Surface Plasmon Resonance

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dc.contributor.advisorKerwin, Sean
dc.contributor.authorMyhre, Mitchell
dc.contributor.committeeMemberDavid, Wendi
dc.contributor.committeeMemberLewis, Karen
dc.date.accessioned2023-09-11T19:54:04Z
dc.date.available2023-09-11T19:54:04Z
dc.date.issued2023-08
dc.description.abstractG-triplex (G3) nucleic acid structures have recently been proposed as common folding intermediates to G-quadruplex (G4) DNA. Studies on the G3 DNA have been limited, and our understanding of their potential physiological function is in its infancy. To date, several putative G3 forming oligonucleotide based on truncated G4 sequences have been identified. However, the competition between multi-molecular G4 formation and intramolecular G3 formation in truncated G4 sequences has called these putative G3’s into question. This project has aimed toward the development of new methods to identify and study G3 DNA in a manner that precludes G4 multimer formation. Utilizing surface plasmon resonance (SPR), we have identified new putative G3 DNA sequences and qualitatively assessed intermolecular interactions of G3 DNA with several DNA binding proteins.
dc.description.departmentChemistry and Biochemistry
dc.formatText
dc.format.extent95 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationMyhre, M. (2023). Intermolecular interactions of G-triplex DNA assessed by multi-channel surface plasmon resonance (Unpublished thesis). Texas State University, San Marcos, Texas.
dc.identifier.urihttps://hdl.handle.net/10877/17127
dc.language.isoen
dc.subjectG-quadruplex DNA
dc.subjectG-triplex DNA
dc.subjectsurface plasmon resonance
dc.subjectChemistry and Biochemistry
dc.titleIntermolecular Interactions of G-Triplex DNA Assessed by Multi-Channel Surface Plasmon Resonance
dc.typeThesis
thesis.degree.departmentChemistry and Biochemistry
thesis.degree.disciplineBiochemistry
thesis.degree.grantorTexas State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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