Exogenous Superoxide Dismutase and Catalase Prevent Reperfusion Injury in Rat Myocardium and may be Transported From Capillaries Into Myocytes
dc.contributor.advisor | Koke, Joseph R. | |
dc.contributor.author | Christodoulides, Nicolaos Joseph | |
dc.contributor.committeeMember | Aron, Gary M. | |
dc.contributor.committeeMember | Irvin, James D. | |
dc.date.accessioned | 2024-05-07T16:51:07Z | |
dc.date.available | 2024-05-07T16:51:07Z | |
dc.date.issued | 1989-05 | |
dc.description.abstract | The effects of infusing superoxide dismutase (SOD)and catalase (CAT) into the coronary circulation were investigated in rat hearts (isolated, working) prior to and during a 15 minute episode of regional ischemia followed by 30 minutes reperfusion. Aortic output (AO), left ventricular pressure (L VP) and dP/dT of L VP were recorded. Compared to sham treated hearts, SOD and CAT significantly improved function during reperfusion, but had no effect during the pre-ischemic or the ischemic period. Cryotome sections of isolated, angendorf[ perfused (with or without SOD or CAT) rat hearts were exposed to rabbit antibody prepared against the exogenous SOD and CAT. Bound antibody was detected by the indirect-fluorescent antibody test. The interior of myocytes from rat hearts exposed to SOD and CAT bound antibodies prepared against these enzymes; whereas, myocytes from rat hearts not exposed to exogenous SOD and CAT only bound the CAT antibodies. This indicates the anti-SOD we prepared is specific for exogenous SOD, and also suggests exogenous SOD is transported efficiently from the coronary circulation into the cytoplasm of myocytes. | |
dc.description.department | Biology | |
dc.format | Text | |
dc.format.extent | 46 pages | |
dc.format.medium | 1 file (.pdf) | |
dc.identifier.citation | Christodoulides, N.J. (1989). Exogenous superoxide dismutase and catalase prevent reperfusion injury in rat myocardium and may be transported from capillaries into myocytes (Unpublished thesis). Southwest Texas State University, San Marcos, Texas. | |
dc.identifier.uri | https://hdl.handle.net/10877/18568 | |
dc.language.iso | en | |
dc.subject | catalase | |
dc.subject | myocardium | |
dc.subject | rats | |
dc.subject | cardiovascular system | |
dc.title | Exogenous Superoxide Dismutase and Catalase Prevent Reperfusion Injury in Rat Myocardium and may be Transported From Capillaries Into Myocytes | |
dc.type | Thesis | |
thesis.degree.department | Biology | |
thesis.degree.discipline | Biology | |
thesis.degree.grantor | Southwest Texas State University | |
thesis.degree.level | Masters | |
thesis.degree.name | Master of Science |
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