Koh, Gar YeeTeoh, Chin May2023-05-052023-05-052023-05Teoh, C. M. (2023). The impact of maternal methyl-donor nutrient supplementation on vitamin D status and inflammation among adult offspring (Unpublished thesis). Texas State University, San Marcos, Texas.https://hdl.handle.net/10877/16719Maternal overweight and obesity is associated with higher risks of childhood obesity. Low vitamin D (VD) status is often observed among overweight and obese (OWO) individuals, enhancing their risk for the development of secondary complications, such as inflammatory bowel diseases, cardiovascular diseases, and cancers. In addition to its classical role in bone health, the immunomodulatory role of VD has been widely reported. In this study, we aim to investigate the effect of maternal methyl-donor nutrient supplementation (MS) to a high-fat high-sucrose (HFS) diet during pregnancy and lactation on VD status and inflammation among offspring. Our results suggest a critical role of prenatal MS in mediating VD status among offspring and suppressing systemic inflammation in offspring. We further demonstrated that prenatal and postnatal diets differentially regulate renal and colonic VD signaling, as well as the respective local inflammatory signaling. Mechanisms by which prenatal and postnatal diets regulate VD signaling locally remained to be elucidated. Collectively, this thesis project supported the role of prenatal dietary modifications in optimizing VD status as a strategy to prevent the development of metabolic disorders.Text76 pages1 file (.pdf)enmaternalvitamin DinflammationThesis