Lu, YuanStarkey, NicholasLei, WeiLi, JilongCheng, JianlinFolk, William R.Lubahn, Dennis2021-08-092021-08-092015-12-28Lu, Y., Starkey, N., Lei, W., Li, J., Cheng, J., Folk, W. R., & Lubahn, D. B. (2015). Inhibition of hedgehog-signaling driven genes in prostate cancer cells by Sutherlandia frutescens extract. PLoS One, 10(12), e0145507.1932-6203https://hdl.handle.net/10877/14260Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cells with or without Sutherlandia extracts. We found 50% of Hh-responsive genes can be repressed by Sutherlandia ethanol extract, including the canonical Hh-responsive genes Gli1 and Ptch1 as well as newly distinguished Hh-responsive genes Hsd11b1 and Penk.Text9 pages1 file (.pdf)enprostate cancergene expressioncancer treatmentcolorectal cancersmall cell lung cancergene ontologiesethanolprostate glandChemistry and BiochemistryArticle© 2015 Lu et al.https://doi.org/10.1371/journal.pone.0145507This work is licensed under a Creative Commons Attribution 4.0 International License.