Kornienko, AlexanderLa Clair, James2019-10-172019-10-172017-08Kornienko, A., La Clair, J. (2017). Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Natural Product Reports, 34(9), pp. 1051–1060.0265-0568https://hdl.handle.net/10877/8677Natural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems.Text34 pages1 file (.pdf)ennatural productsendogenous metabolitesPaal-Knorr pyrrole formationChemistry and BiochemistryArticlehttps://doi.org/10.1039/c7np00024c