Xue, XiaovuEliaz, LillianEyaa, Darriel2024-04-112024-04-112024-03Xue, X., Eliaz, L., & Eyaa, D. (2024). Molecular mechanism of the interplay between human BRCA1-BARD1 and DNA/RNA helicase ZGRF1 in R-loop resolution and genome maintenance. Poster presented at the Health Scholar Showcase, Translational Health Research Center, San Marcos, Texas.https://hdl.handle.net/10877/18424R-loops form upon hybridization of RNA with a complementary strand in duplex DNA. R-loops are a major source of DNA damage, replication stress and genome instability. Cells have evolved different strategies to prevent R-loop accumulation. One mechanism relies on the deployment of DNA/RNA helicases for R-loop resolution. Recent studies have revealed that depletion of these specialized DNA/RNA helicases results in the accumulation of DNA/RNA hybrids and R-loops in cell. However, major knowledge gaps remain regarding how these helicases recognize and dissociate R-loops to avoid chromosome damage and how their function is regulated.Image1 page1 file (.pdf)enDNARNAgenome maintenancemolecularPoster