Snyder, DavidFarrell, Megan K.2018-11-142018-11-142018-11Farrell, M. K. (2018). <i>Using knot theory to model and analyze DNA replication and recombination</i> (Unpublished thesis). Texas State University, San Marcos, Texas.https://hdl.handle.net/10877/7783Due to DNA supercoiling inside the nucleus of a cell, DNA can be modeled as a mathematical knot. We will analyze and examine the knots and links that arise after single or multiple rounds of DNA recombi- nation using the tangle model. We will also examine how the topology of a DNA strand is modified during DNA replication and which enzymes directly alter the topology of the strand. The goal is to better understand the mechanism of site-specific recombination and knotted DNA replication through mathematical models.Text53 pages1 file (.pdf)enKnot TheoryTopologyDNAMath modelingTangle modelTanglesKnot theoryDNA replicationThesis