Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance

Simple item page
dc.contributor.authorCiavatta, Maria Letizia
dc.contributor.authorLefranc, Florence
dc.contributor.authorCarbone, Marianna
dc.contributor.authorMollo, Ernesto
dc.contributor.authorGavagnin, Margherita
dc.contributor.authorBetancourt, Tania
dc.contributor.authorDasari, Ramesh
dc.contributor.authorKornienko, Alexander
dc.contributor.authorKiss, Robert
dc.date.accessioned2020-04-13T15:30:50Z
dc.date.available2020-04-13T15:30:50Z
dc.date.issued2016-12
dc.description.abstractThe chemical investigation of marine mollusks has led to the isolation of a wide variety of bioactive metabolites, which evolved in marine organisms as favorable adaptations to survive in different environments. Most of them are derived from food sources, but they can be also biosynthesized de novo by the mollusks themselves, or produced by symbionts. Consequently, the isolated compounds cannot be strictly considered as "chemotaxonomic markers" for the different molluscan species. However, the chemical investigation of this phylum has provided many compounds of interest as potential anticancer drugs that assume particular importance in the light of the growing literature on cancer biology and chemotherapy. The current review highlights the diversity of chemical structures, mechanisms of action, and, most importantly, the potential of mollusk-derived metabolites as anticancer agents, including those biosynthesized by mollusks and those of dietary origin. After the discussion of dolastatins and kahalalides, compounds previously studied in clinical trials, the review covers potentially promising anticancer agents, which are grouped based on their structural type and include terpenes, steroids, peptides, polyketides and nitrogen-containing compounds. The "promise" of a mollusk-derived natural product as an anticancer agent is evaluated on the basis of its ability to target biological characteristics of cancer cells responsible for poor treatment outcomes. These characteristics include high antiproliferative potency against cancer cells in vitro, preferential inhibition of the proliferation of cancer cells over normal ones, mechanism of action via nonapoptotic signaling pathways, circumvention of multidrug resistance phenotype, and high activity in vivo, among others. The review also includes sections on the targeted delivery of mollusk-derived anticancer agents and solutions to their procurement in quantity.
dc.description.departmentChemistry and Biochemistry
dc.formatText
dc.format.extent100 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationCiavatta, M. L., Lefranc, F., Carbone, M., Mollo, E., Gavagnin, M., Betancourt, T., Dasari, R., Kornienko, A., & Kiss, R. (2016). Marine mollusk-derived agents with antiproliferative activity as promising anticancer agents to overcome chemotherapy resistance. Medicinal Research Reviews, 37(4), pp. 702–801.
dc.identifier.doihttps://doi.org/10.1002/med.21423
dc.identifier.issn1098-1128
dc.identifier.urihttps://hdl.handle.net/10877/9588
dc.language.isoen
dc.publisherWiley Periodicals, Inc.
dc.rights.holder© 2016 The Authors Medicinal Research Reviews
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
dc.sourceMedicinal Research Reviews, 2016, Vol. 37, No. 4, pp. 702–801.
dc.subjectmollusk
dc.subjectcancer
dc.subjectpreclinical evaluation
dc.subjecttargeted delivery
dc.subjecttreatment
dc.subjectinnovative mechanism of action
dc.subjectChemistry and Biochemistry
dc.titleMarine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
MED-37-702.pdf
Size:
4.19 MB
Format:
Adobe Portable Document Format
Description:
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.54 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

College of Science and Engineering