Localization of Luteinizing Hormone-Releasing Hormone (LHRH) in the Hypothalamus of Fetal Bovine




DeSimone, Ivy

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Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) are mammalian gonadotropins released from the anterior pituitary by Gonadotropin Releasing Hormone (GnRH) in the hypothalamus. Various analogs ofGnRH have been identified. Localization of these hormones is the first step in discovering the individual function of each analog. Immunohistochemistry and confocal microscopy were used to localize Luteinizing Hormone Releasing Hormone (LHRH), also known as mammalian GnRH, in the fetal bovine hypothalamus. This analog is believed to differentiate the pituitary primordia during embryonic development and initiate the release ofLH throughout the life of the animal. Localization of LHRH bound to neuronal membranes began from embryonic day 100 of gestation through term. Spatially neurons were located throughout the hypothalamus. Specifically, LHRH neurons were identified in most of the tissue observed from the most anterior sections including the OVL T and preoptic, rostral hypothalamus, extending as far caudally as the medial mammillary nucleus and axons were observed in the median eminence and ventral to the third ventricle.



luteinizing hormone releasing hormone, follicle, gonadotropin, hypothalamus, cattle, neurons, embryos, stimulating hormone


DeSimone, I. (2001). Localization of luteinizing hormone-releasing hormone (LHRH) in the hypothalamus of fetal bovine (Unpublished thesis). Southwest Texas State University, San Marcos, Texas.


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