Covalent Modification of Biological Targets with Natural Products through Paal-Knorr pyrrole Formation
dc.contributor.author | Kornienko, Alexander | |
dc.contributor.author | La Clair, James | |
dc.date.accessioned | 2019-10-17T16:11:53Z | |
dc.date.available | 2019-10-17T16:11:53Z | |
dc.date.issued | 2017-08 | |
dc.description.abstract | Natural products and endogenous metabolites engage specific targets within tissues and cells through complex mechanisms. This review examines the extent to which natural systems have adopted the Paal-Knorr reaction to engage nucleophilic amine groups within biological targets. Current understanding of this mode of reactivity is limited by only a few examples of this reaction in a biological context. This highlight is intended to stimulate the scientific community to identify potential research directions and applications of the Paal-Knorr reaction in native and engineered biological systems. | |
dc.description.department | Chemistry and Biochemistry | |
dc.description.version | This is the accepted manuscript version of an article published in Natural Product Reports. | |
dc.format | Text | |
dc.format.extent | 34 pages | |
dc.format.medium | 1 file (.pdf) | |
dc.identifier.citation | Kornienko, A., La Clair, J. (2017). Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Natural Product Reports, 34(9), pp. 1051–1060. | |
dc.identifier.doi | https://doi.org/10.1039/c7np00024c | |
dc.identifier.issn | 0265-0568 | |
dc.identifier.uri | https://hdl.handle.net/10877/8677 | |
dc.language.iso | en | |
dc.publisher | Royal Society of Chemistry | |
dc.source | Natural Product Reports, 2017, Vol. 34, No. 9, pp. 1051–1060. | |
dc.subject | natural products | |
dc.subject | endogenous metabolites | |
dc.subject | Paal-Knorr pyrrole formation | |
dc.subject | Chemistry and Biochemistry | |
dc.title | Covalent Modification of Biological Targets with Natural Products through Paal-Knorr pyrrole Formation | |
dc.type | Article |