Adiponectin Influences FGF2 in the Developing Porcine Corpus Luteum




Flores, Rita
Ramirez, Martha
Ayala, Luis
Benavides, Elizabeth
Xie, Fang
Arellano, Adrian
Stanko, Randy
Garcia, Michelle

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Multidisciplinary Digital Publishing Institute


Luteal angiogenesis is regulated by pro-angiogenic hormones including fibroblast growth factor 2 (FGF2) and angiopoietin 1 (Ang1), which are regulated by the adipokine leptin during development. Another adipokine, adiponectin, exhibits an inverse relationship with leptin and has been identified in the CL. Therefore, it is hypothesized that adiponectin will influence pro-angiogenic hormones in the developing porcine CL. Crossbred sows were randomly allocated to one of two days of the estrous cycle, day 5 (D5; n = 4) or day 7 (D7; n = 5) for CL collection. Tissue was processed for immunohistochemical localization of adiponectin receptor 2 (AdipoR2), gene expression of FGF2, Ang1, leptin, AdipoR2, and cell culture for adiponectin treatment. The expression of AdipoR2 tended (p = 0.09) to be higher in D7 lutea and was more prevalently localized to the cell surface of large and small luteal cells than in D5 tissue. Adiponectin influenced (p ≤ 0.05) FGF2, leptin, and AdipoR2 gene expression relative to the dose and day (D5 or D7). Collectively, the evidence supports the supposition that adiponectin influences angiogenic factors in the developing CL.



adiponectin, FGF2, AdipoR2, CL, porcine, Agricultural Sciences


Flores, R., Ramirez, M., Ayala, L., Benavides, E. A., Xie, F., Arellano, A. A., Stanko, R. L., & Garcia, M. R. (2022). Adiponectin influences FGF2 in the developing porcine corpus luteum. Veterinary Sciences, 9(2), 77.


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