Transgender Youth and the Effects of Gender-Affirming Hormone Therapy on Suicidality: A Systematic Review [paper]




Forbes, Melissa

Journal Title

Journal ISSN

Volume Title



Introduction: This research delves into the impact of gender-affirming hormone therapy on depression, suicidality, and quality of life among transgender youth. With increasing recognition of the importance of affirming medical care for transgender youth, this study aims to examine the specific effects of hormone therapy on mental health and overall well-being among this demographic. Methods: A comprehensive literature review was conducted, encompassing studies published between 2018 and 2023. Databases including PubMed, CINAHL, MEDLINE Complete, Academic Search Complete, and ScienceDirect were utilized to collect relevant articles, focusing on research that explored the effects of gender-affirming hormone therapy on suicidality. Studies employing longitudinal designs, cohort studies, and case studies were included to ensure a comprehensive understanding of the topic. Results: The synthesis of findings from the selected studies consistently demonstrates a significant association between gender-affirming hormone therapy and improvements in depression symptoms, decreased suicidality rates, and enhanced overall quality of life among transgender youth. Various measures, such as standardized mental health assessments and self-reported outcomes, consistently indicate positive outcomes following the initiation of hormone therapy. Discussion: The implications of these findings highlight the critical role of gender-affirming hormone therapy in positively influencing mental health outcomes and well-being among transgender youth. The observed reductions in depression symptoms and suicidality, coupled with improved quality of life, underscore the importance affirming healthcare for this population. Further exploration into the effects and diverse experiences of transgender youth undergoing hormone therapy is recommended to enhance comprehensive care and support for this community.


An EBP Capstone Project submitted to the St. David’s School of Nursing at Texas State University in partial fulfillment of the requirements for the degree of Master of Science in Nursing.


transgender youth, gender-affirming hormone therapy, depression, suicidality, quality of life, mental health


Forbes, M. (2023). Transgender youth and the effects of gender-affirming hormone therapy on suicidality: A systematic review [paper]. St. David's School of Nursing, Texas State University.


Rights Holder

Rights License

Rights URI