Interventions to Manage Weight Gain for Pediatric Population on Antipsychotics: A Systematic Review [paper]




Gaytan, Claudia

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This article systemically reviews studies that present interventions related to pharmacological and non-pharmacological treatment for the weight management and reduction of pediatric patients prescribed antipsychotics. Using PRISMA guidelines, various databases such as PubMed, CINAHL, PubMed Central and Medline were searched using key words of “weight gain,” “BMI,” antipsychotics,” “pediatrics,” “children,” “pharmacological,” “nonpharmacological,” “interventions,” and “bipolar disorder.” The initial search yielded 1,800 results, 315 were excluded due to duplicates, and 1,451 excluded due to age of the population. There were seven articles including randomized controlled trials, a quasi-experiment and a retrospective chart review. Metformin was found to be the most studied and effective adjunctive medication for weight management, with promising results of melatonin, zonisamide, and topiramate. Four studies showed a decrease or stabilization of weight with an adjunct dose of metformin with the patient’s antipsychotic. Also found to be effective was switching to a different antipsychotic. Non-pharmacologic methods was found to be unhelpful. More studies are needed on other treatment options to guide clinicians in their treatment practices.



weight gain, pediatric, antipsychotic, pharmacologic, body Mass Index, Nursing


Gaytan, C. (2022). Interventions to manage weight gain for pediatric population on antipsychotics: A systematic review [Report]. St. David's School of Nursing, Texas State University.


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