An evaluation of congenital hypothyroidism in Texas, 1992-1995




Elerian, Nagla F.

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Congenital hypothyroidism is a biochemical defect that can have devastating effects on a child if undetected or untreated. The rate of congenital hypothyroidism in Texas has been on the increase since 1991. Rates in Texas far exceed observed rates nation wide. This study is an attempt to characterize the distribution of congenital hypothyroidism in Texas. It examined the effects of race/ethnicity, gender and maternal age on the rate of congenital hypothyroidism. Research evidence points to these variables as possible risk factors in congenital anomalies, including congenital hypothyroidism. In addition, this study examined the seasonality of congenital hypothyroidism in order to assess the possibility of environmental effects. The study spanned the period from 1992 to 1995 and covered the entire state of Texas. During that period, there were a total of 1,286,432 births of which 806 cases of congenital hypothyroidism were identified. Odds Ratio analysis and Logistic Regression were used to assess race/ethnicity, gender, and maternal age as risk factors. Time Series analysis was used to assess the seasonality effect. Results indicate that Hispanic race/ethnicity, female gender and advanced maternal age, in that order, significantly increase the rate of congenital hypothyroidism. The need for prenatal screening and outreach programs for at risk population was stressed. Further studies were suggested.



congenital hypothyroidism, hypothyroidism, genetics


Elerian, N. F. (1999). An evaluation of congenital hypothyroidism in Texas, 1992-1995 (Unpublished thesis). Southwest Texas State University, San Marcos, Texas.


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