Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract

Lu, Yuan
Starkey, Nicholas
Lei, Wei
Li, Jilong
Cheng, Jianlin
Folk, William R.
Lubahn, Dennis
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Public Library of Science
Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cells with or without Sutherlandia extracts. We found 50% of Hh-responsive genes can be repressed by Sutherlandia ethanol extract, including the canonical Hh-responsive genes Gli1 and Ptch1 as well as newly distinguished Hh-responsive genes Hsd11b1 and Penk.
prostate cancer, gene expression, cancer treatment, colorectal cancer, small cell lung cancer, gene ontologies, ethanol, prostate gland, Chemistry and Biochemistry
Lu, Y., Starkey, N., Lei, W., Li, J., Cheng, J., Folk, W. R., & Lubahn, D. B. (2015). Inhibition of hedgehog-signaling driven genes in prostate cancer cells by Sutherlandia frutescens extract. PLoS One, 10(12), e0145507.