The Effects of TMPyP4 on G-Quadruplex Forming Oligonucleotides
| dc.contributor.advisor | David, Wendi | |
| dc.contributor.author | Gonzalez, Daniella | |
| dc.date.accessioned | 2022-07-13T17:03:52Z | |
| dc.date.available | 2022-07-13T17:03:52Z | |
| dc.date.issued | 2022-05 | |
| dc.description.abstract | The ability of guanine-rich DNA to adopt various folded forms is well-established and these G-quadruplex structures are likely involved in telomere maintenance. The folded structures are stabilized in solution by binding of cations such as Na+ and certain small molecule ligands. One such ligand, TMPyP4, has previously been demonstrated to interfere with telomeric DNA processing by binding to G-quadruplexes in the DNA. However, for the G-quadruplex forming oligonucleotide, Tel22 (based on the human telomeric DNA sequence) TMPyP4 significantly decreases the stability of the folded structure in the presence of varying levels of Na+ ion. This destabilization is unusual and implications for further studies are discussed. | |
| dc.description.department | Chemistry and Biochemistry | |
| dc.format | Text | |
| dc.format.extent | 12 pages | |
| dc.format.medium | 1 file (.pdf) | |
| dc.identifier.citation | Gonzalez, D. C. (2022). The effects of TMPyP4 on G-quadruplex forming oligonucleotides (Unpublished thesis). Texas State University, San Marcos, Texas. | |
| dc.identifier.uri | https://hdl.handle.net/10877/15951 | |
| dc.language.iso | en | |
| dc.subject | G-quadruplex | |
| dc.subject | ligands | |
| dc.subject | TMPyP4 | |
| dc.subject | molecular interactions | |
| dc.title | The Effects of TMPyP4 on G-Quadruplex Forming Oligonucleotides | |
| dc.type | Thesis | |
| thesis.degree.department | Honors College | |
| thesis.degree.discipline | Chemistry and Biochemistry | |
| thesis.degree.grantor | Texas State University |