Molecular mechanism of the interplay between human BRCA1-BARD1 and DNA/RNA helicase ZGRF1 in R-loop resolution and genome maintenance
| dc.contributor.author | Xue, Xiaovu | |
| dc.contributor.author | Eliaz, Lillian | |
| dc.contributor.author | Eyaa, Darriel | |
| dc.date.accessioned | 2024-04-11T14:11:28Z | |
| dc.date.available | 2024-04-11T14:11:28Z | |
| dc.date.issued | 2024-03 | |
| dc.description.abstract | R-loops form upon hybridization of RNA with a complementary strand in duplex DNA. R-loops are a major source of DNA damage, replication stress and genome instability. Cells have evolved different strategies to prevent R-loop accumulation. One mechanism relies on the deployment of DNA/RNA helicases for R-loop resolution. Recent studies have revealed that depletion of these specialized DNA/RNA helicases results in the accumulation of DNA/RNA hybrids and R-loops in cell. However, major knowledge gaps remain regarding how these helicases recognize and dissociate R-loops to avoid chromosome damage and how their function is regulated. | |
| dc.description.department | Chemistry and Biochemistry | |
| dc.format | Image | |
| dc.format.extent | 1 page | |
| dc.format.medium | 1 file (.pdf) | |
| dc.identifier.citation | Xue, X., Eliaz, L., & Eyaa, D. (2024). Molecular mechanism of the interplay between human BRCA1-BARD1 and DNA/RNA helicase ZGRF1 in R-loop resolution and genome maintenance. Poster presented at the Health Scholar Showcase, Translational Health Research Center, San Marcos, Texas. | |
| dc.identifier.uri | https://hdl.handle.net/10877/18424 | |
| dc.language.iso | en | |
| dc.source | Health Scholar Showcase, 2024, Texas State University Translational Health Science Center, San Marcos, Texas, United States. | |
| dc.subject | DNA | |
| dc.subject | RNA | |
| dc.subject | genome maintenance | |
| dc.subject | molecular | |
| dc.title | Molecular mechanism of the interplay between human BRCA1-BARD1 and DNA/RNA helicase ZGRF1 in R-loop resolution and genome maintenance | |
| dc.type | Poster |